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Hyalase (Hyaluronidase) - Dissolving Dermal Fillers in Singapore
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Hyalase is a medical solution containing hyaluronidase, a naturally occurring enzyme that breaks down hyaluronic acid. It is used to dissolve hyaluronic acid-based dermal fillers that have been incorrectly placed or injected in excessive amounts. This process allows for safe and controlled correction of filler treatments, addressing issues such as overfilled cheeks, asymmetry, or visible lumps. Poorly executed filler injections can also result in fillers sticking out or protruding, which detracts from a natural appearance.
Hyalase can be used to adjust or dissolve fillers in various treatment areas such as the cheeks, chin, and tear troughs.
Excess volume from previous treatments can cause unnatural results, which Hyalase can correct to help restore a more balanced and natural look.
What Is Hyalase?
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Composition of Hyalase
Hyalase contains hyaluronidase enzymes, which are very specific enzymes responsible for breaking down hyaluronic acid in the body. Hyaluronic acid is naturally found in connective tissue and the extracellular matrix, supporting hydration and skin structure.
Role of Hyaluronidase
Hyaluronidase is responsible for hyaluronic acid turnover in the body. The activity of hyaluronidase can be affected by various drugs and physiological conditions, which may alter its effectiveness in breaking down hyaluronic acid. It interacts with binding sites within hyaluronic acid to chemically break the filler into simpler sugars that the body can absorb.
Medical History and Uses
Hyaluronidase has been used in aesthetic medicine and general medicine for over 60 years. Beyond dissolving dermal fillers, it increases drug absorption and improves the absorption and dispersion of drugs and contrast media in various treatments due to its enzymatic activity, rather than any role related to food. It aids subcutaneous fluid infusion and is also used in subcutaneous urography, where it enhances the absorption of contrast media for urinary tract imaging, and reduces tissue damage in cases of extravasation.
How Hyalase Works on Dermal Fillers
Mechanism of Action
Hyalase chemically breaks the bonds in hyaluronic acid, turning the filler into a substance the body can naturally absorb. Its effect depends on the filler’s hyaluronic acid concentration, number of cross-links, and the form of the filler (e.g., cross-linked hyaluronic acid).
Types of Fillers It Can Dissolve
Hyalase is effective only on hyaluronic acid-based fillers and does not work on non-dissolvable fillers or gels. It can correct complications such as overfilled lips, asymmetry, eye lumps, witch’s chin, or avatar nose.
Timing and Effectiveness
The filler-dissolving effect lasts 3–6 hours after injection. Sufficient enzyme dose must be administered close to the target filler for effective dissolution.
Who is Suitable for Treatment
Hyaluronidase is suitable for healthy adults who have received hyaluronic acid-based filler injections and want to refine or reverse results. It is ideal for correcting overfilled cheeks, eye lumps, uneven fillers, or adjusting aesthetic plans. A consultation with a qualified professional is recommended to ensure safe and effective treatment.
Pre-Treatment Instructions
Before treatment, avoid blood thinners, vitamin E, fish oil, and non-prescribed anti-inflammatories or antihistamines 24 hours prior. Inform your doctor of any medical conditions like diabetes, high blood pressure, or autoimmune disorders. Discuss your medical history and expectations to ensure safe and effective use of hyaluronidase.
Administration and Procedure
Injection Techniques
Hyalase is injected using either a tiny sharp needle or micro cannula. Sharp needles are preferred for small areas like the nose or chin, while micro cannulas are used for larger areas like the cheeks.
Treatment Duration
The procedure usually takes around 15 minutes per treatment area. Most patients achieve results within 24 hours. Large volumes may require a second session.
Safety Considerations
Allergic and Adverse Reactions
Although rare, allergic reactions to hyaluronidase can occur. Immediate hypersensitivity appears within 1–2 hours as erythematous edema, while delayed reactions may appear after 24 hours. The incidence is between 0.05%–0.69%.
Recommended Precautions
Doctors generally advise a skin test (patch test) before treatment for patients with known allergies. Injection should be avoided in patients with severe allergies to enzyme components.
Applications in Aesthetic Medicine
Correcting Unsatisfactory Results
Hyalase allows patients to correct overfilled areas, lumps, asymmetry, or migrated fillers. It can restore proper filler positioning in the same area or enable a fresh plan for future filler treatments.
Re-Treatment and Adjustments
Patients may choose Hyalase treatment to adjust previous filler injections or to experiment with different products. This provides flexibility in aesthetic planning and ensures precise treatment outcomes.
Medical Emergency Use
Hyalase is also used in emergencies such as vascular occlusion, where fillers block blood vessels. Prompt dissolution minimizes tissue damage.
Cost and Accessibility
Pricing in Singapore
The price to dissolve dermal fillers with Hyalase starts from $600 per session.
Quick Recovery
Hyalase treatment is brief and safe, allowing patients to resume normal activities quickly. Most patients require only one session for complete correction.