304 Orchard Road, #05-29, Singapore 238863
Disclaimer: In line with HSA regulations, specific brand names are not mentioned on this page.
Introduction to Weekly Semaglutide Injections for Weight Loss
What is semaglutide injection? Semaglutide injection is a prescription medication belonging to the class of GLP-1 RAs (glucagon-like peptide-1 receptor agonists) and is approved in Singapore for the treatment of obesity and weight management. Semaglutide injections are available in Singapore for individuals seeking medical weight management, and are approved in Singapore for the treatment of obesity and weight management. Developed and manufactured by Novo Nordisk, semaglutide injection is a medically supervised treatment used in Singapore for medically supervised approach to weight loss
When combined with a reduced-calorie diet and regular physical activity, semaglutide works to suppress appetite, improve satiety, and regulate blood sugar levels—resulting in clinically studied weight reduction over time for weight management.
This guide provides essential information for those considering semaglutide as part of a structured medical weight loss program in Singapore.
Approved for Weight Loss: Regulatory Status in Singapore
In Singapore, semaglutide injections—including GLP-1 receptor agonists —are approved for weight loss treatment under the oversight of the Health Sciences Authority (HSA). These prescription medications are rigorously evaluated to ensure they meet high standards for safety and effectiveness before being made available for individuals seeking medical weight loss solutions.
As a GLP-1 receptor agonist, semaglutide works by helping to reduce body weight and improve metabolic health, making it an option considered for medical weight management or weight-related health concerns. Semaglutide injections are typically administered once weekly, and their use is carefully monitored by healthcare professionals to manage potential side effects and optimize outcomes.
For anyone considering weight loss injections in Singapore, it is important to consult with a qualified doctor to determine if these medications are suitable and to receive ongoing support throughout the treatment process.
How Weekly Semaglutide Injections Work
Semaglutide mimics the action of glucagon-like peptide-1 (GLP-1), a natural hormone that regulates hunger and glucose metabolism. The effects of GLP-1 and GLP-1 receptor agonists include reducing appetite and improving blood sugar regulation by enhancing insulin secretion and slowing gastric emptying. Wegovy and other GLP-1 RAs (receptor agonists) share similar mechanisms of action, targeting the GLP-1 receptor to support weight management and glycemic control.
The effects of semaglutide injection include significant weight loss and improvements in metabolic health, making it used in the management of obesity and type 2 diabetes.
-
Acts on areas of the brain involved in appetite control
-
Slows gastric emptying to help patients feel full for longer
-
Activation of GLP-1 receptor: The effects of GLP-1 receptor activation include reduced appetite, improved insulin secretion, and better blood sugar control, all of which contribute to weight loss and diabetes management
Key Mechanisms:
-
Suppresses appetite and reduces food cravings
-
Enhances satiety, helping you feel full with smaller meals
-
Improves blood sugar control by increasing insulin and decreasing glucagon secretion
-
Supports long-term weight loss when used with lifestyle changes
Administered as a once-weekly subcutaneous injection, this medication is suitable for those seeking a convenient, non-daily alternative to traditional weight loss treatments.
Results from Clinical Trials: Evidence for Semaglutide
Extensive clinical research supports the effectiveness of semaglutide injections for weight loss treatment. In major studies, such as the STEP-1 trial, participants who received semaglutide 2.4 mg once weekly experienced significant reductions in body weight compared to those given a placebo. These results highlight the potential of semaglutide as a medical weight loss solution, especially when combined with a healthy diet and regular exercise as part of a comprehensive weight management plan.
The evidence demonstrates that semaglutide injections, including those marketed as Ozempic and Wegovy, can help individuals achieve meaningful weight loss and improve overall health. For those seeking a proven, doctor-supervised approach to weight loss in Singapore, semaglutide offers a promising option supported by robust clinical data.
Benefits of Weekly GLP-1 Weight Loss Injections
Semaglutide offers a range of medically validated benefits when prescribed as part of a structured, doctor-supervised program:
-
Clinical trials have reported average weight loss of up to 15% in some patientsin clinical trials, with the timeline of weight loss varying based on individual response and duration of treatment
-
Appetite suppression and reduced cravings
-
Improved insulin sensitivity and metabolic health
-
Support for better blood pressure and cholesterol management
-
Convenient once-weekly dosing
Other medications, such as Victoza, contain the same active ingredient as weekly GLP-1 injections, offering similar benefits for appetite control and weight loss. Saxenda, which also contains liraglutide, is another GLP-1 receptor agonist approved specifically for weight management.
These benefits make it a commonly used for individuals who have struggled with weight loss through diet and exercise alone.
Who is Eligible for Weekly Semaglutide Injections in Singapore?
Weekly semaglutide injections can be prescribed for adults who meet any of the following criteria:
-
BMI ≥ 30 (classified as obesity)
-
BMI ≥ 27 with at least one weight-related condition, such as:
-
Type 2 diabetes
-
High blood pressure
-
High cholesterol
-
Fatty liver disease
-
Obstructive sleep apnea
❌ This treatment may not be suitable for individuals who are:
Pregnant or breastfeeding
Diagnosed with pancreatitis or gallbladder disease
Have a personal or family history of medullary thyroid carcinoma or MEN2
A comprehensive medical assessment is required to confirm your suitability.
Treatment Journey: What to Expect
Step 1: Initial Consultation
Our doctor will evaluate your medical history, lifestyle, and weight loss goals before prescribing treatment.
Step 2: Dose Titration Phase
Treatment begins with a low starting dose to allow your body to adjust. The dosage is gradually increased every few weeks until reaching a maintenance level (usually 2.4mg/week).
Step 3: Self-Administration
Injections are performed once a week into the abdomen, thigh, or upper arm. You will be trained on proper injection techniques and site rotation.
Step 4: Progress Monitoring
Ongoing follow-up appointments will help monitor your weight loss, adjust your plan, and manage any side effects.
Duration of Treatment: How Long Will You Need Semaglutide?
The length of time you may need semaglutide injections for weight loss depends on your starting body weight, personal goals, and how your body responds to treatment. Many individuals use semaglutide, such as Ozempic and Wegovy, for several months to a year or longer, with regular check-ins to track progress and adjust the plan as needed.
For long-term weight management, it’s important to pair semaglutide with healthy lifestyle changes to reduce the risk of regaining weight after stopping the medication. Our doctor will work with you to determine the most appropriate treatment duration and help you develop strategies for maintaining your results over time, ensuring that your weight loss journey is both safe and sustainable.
Expected Results: Weight Loss Timeline
-
Weeks 1–4: Appetite suppression and early satiety become noticeable. Initial water weight loss may occur on the first few weeks.
-
Weeks 5–12: Steady fat loss begins as calorie intake continues to decrease, with changes becoming more apparent on the following weeks.
-
Weeks 13–68: Long-term weight loss progresses, with clinical studies showing up to 15%–20% reduction in body weight over one year with consistent use and lifestyle changes on the recommended schedule.
Side Effects and Safety
Semaglutide is generally well-tolerated. However, some patients may experience temporary side effects as the body adjusts to treatment. It is important to be aware of the possible side effects of semaglutide injection, which can include mild gastrointestinal issues, injection site reactions, headaches, and fatigue.
The side effects of semaglutide and other GLP-1 receptor agonists are typically temporary and improve over time, but consulting with a healthcare provider is recommended for individualized advice.
Common Side Effects:
-
Nausea
-
Constipation
-
Diarrhea
-
Abdominal bloating
Less Common, Serious Side Effects:
-
Pancreatitis
-
Gallbladder issues
-
Kidney problems
Our doctor will monitor for these during your treatment journey. Any new symptoms should be reported immediately.
Managing Side Effects
To reduce discomfort during the first few weeks of treatment:
-
Eat small, frequent meals
-
Avoid greasy or high-fat foods
-
Stay well hydrated
-
Avoid overeating, even if food intake is reduced
-
Our doctor may adjust your dosage or prescribe anti-nausea medication if needed
Transitioning Off Semaglutide: What Happens Next?
When it’s time to stop semaglutide, working closely with your healthcare provider is essential to maintain your weight loss and minimize the risk of regaining weight. After discontinuing semaglutide, some individuals may notice an increase in appetite or cravings, which can make it challenging to keep the weight off. To reduce the risk of weight regain and related health issues such as type 2 diabetes or high blood pressure, it’s important to continue practicing healthy habits—like regular exercise and balanced eating—and to monitor your weight and overall health.
In some cases, our doctor may suggest alternative weight loss medications or additional support to help you stay on track. Ongoing care and a proactive approach can help you preserve your progress and protect your long-term health after completing semaglutide treatment.
Lifestyle Support for Maximum Results
To achieve and sustain weight loss, weekly semaglutide injections should be paired with:
-
Balanced nutrition with reduced calories and low processed food intake
-
Regular physical activity (150 minutes per week recommended)
-
Stress management and adequate sleep
-
Accountability through follow-ups and tracking
Conclusion: A Doctor-Led Path to medically supervised approach to weight loss
Weekly semaglutide injections represent , suitable and doctor-supervised weight loss treatment for adults struggling with obesity or weight-related health conditions in Singapore.
With proper medical guidance, lifestyle support, and long-term commitment, this treatment offers a non-surgical option being explored in current clinical use currently available.
Book a Doctor-Led Weight Loss Consultation in Singapore
Weekly semaglutide injections represent , suitable and doctor-supervised weight loss treatment for adults struggling with obesity or weight-related health conditions in Singapore.
With proper medical guidance, lifestyle support, and long-term commitment, this treatment offers a non-surgical option being explored in current clinical use currently available.
FAQ
How Do High-Dose Semaglutide Once-Weekly Weight Loss Injections Work?
High-dose semaglutide reduces appetite and slows stomach emptying to support gradual, doctor-supervised weight loss combined with diet and exercise.
Who Is Eligible for High-Dose Semaglutide Weight Loss Injections?
Adults in Singapore with a BMI ≥27 plus a weight-related condition or BMI ≥30 are typically eligible after medical assessment.
What Results Can I Expect From Once-Weekly High-Dose Semaglutide Therapy?
Patients may lose up to 15% of their body weight over about 68 weeks, depending on adherence and lifestyle changes.
What Are the Most Common Side Effects of High-Dose Semaglutide Injections?
Common side effects include temporary nausea, vomiting, diarrhea, constipation, abdominal pain, headaches, and mild injection-site reactions.
How Safe Is Long-Term Use of High-Dose Semaglutide for Weight Loss?
Long-term use has shown sustained weight loss with a stable safety profile but requires regular medical monitoring.
Can High-Dose Semaglutide Be Used With Other Weight Loss Medications?
Combining with other GLP-1 medications is generally not recommended due to increased side effect risks.
What If I Miss a Dose of My Once-Weekly Injection?
Take the missed dose within five days or skip it and resume your normal schedule if more than five days have passed.
How Long Will I Need to Stay on High-Dose Semaglutide Injections?
Treatment usually lasts six to twelve months but can be extended based on progress and health goals.
Is Weight Regain Likely After Stopping High-Dose Semaglutide Therapy?
Weight regain is possible without maintaining healthy habits, so ongoing lifestyle support is important.
What Is the Cost of High-Dose Semaglutide Once-Weekly Weight Loss Injections in Singapore?
Costs vary by clinic and dosage; contact us clinic directly for current pricing details.