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Knee Injection Singapore: Reduce Pain and Restore Mobility

A model with healthy knee

How Polynucleotide (PN) Injections Work in the Knee

Polynucleotide (PN) knee injections are intra-articular treatments made from high molecular weight DNA fragments extracted from salmon. They help reduce mechanical friction in the knee joint by maintaining elasticity and slowly decomposing over time. Clinical studies have shown that knee pain scores improved significantly after three treatment sessions, with no major adverse reactions reported.

Knee injection procedure using conjuran animation

Introduction to Knee Injections

Knee injections are a treatment option for knee pain and osteoarthritis, aiming to relieve pain and restore mobility in the knee joint. Arthritis, particularly osteoarthritis, is the most common condition treated with knee injections in Singapore. Hyaluronic acid injections and corticosteroid injections are among the most common types of knee injections. The purpose of hyaluronic acid injections is to restore the natural lubrication of the joint by supplementing the levels of hyaluronic acid, while corticosteroid injections help reduce inflammation. The procedure involves these substances being injected into the knee joint or affected area, delivering the medication directly in the joint to target inflammation and pain and improve joint function.

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Knee injections are minimally invasive and provide a non-surgical alternative for individuals with knee osteoarthritis in Singapore. The goal is to improve quality of life and increase activity levels for individuals living with chronic knee pain.

Understanding Knee Anatomy

The knee joint is a complex structure composed of the bones of the knee, cartilage, and synovial fluid working together to enable smooth movement and stability. Osteoarthritis (OA) is one of the most common causes of knee pain and affects the cartilage and synovial fluid in the knee, leading to pain, stiffness, and reduced mobility.

 

Maintaining healthy knee joints is essential for preserving joint mobility and function. Over time, wear and tear from injuries, age, or repetitive strain can lead to degenerative changes in the knee joints, which can result in reduced joint mobility. Effective treatment starts with understanding the structure and how different therapies work to support joint function.

Types of Knee Injections

There are several types of knee injections commonly used in Singapore. At our clinic, we provide Polynucleotide (PN) Injections

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  • Viscosupplementation (Hyaluronic Acid Injections): Hyaluronic acid injections are administered directly into the knee joint to the area of inflammation. They help improve joint lubrication, provide cushioning, reduce friction, and can relieve pain and protect the joint.

  • Corticosteroid Injections: Injected into the knee joint to the site of inflammation, these injections reduce inflammation and provide fast relief.

  • Platelet-Rich Plasma (PRP): Uses the patient’s own blood platelets, injected to the affected area, to stimulate healing and reduce inflammation.

  • Polynucleotide (PN) Injections: A new generation of treatment using long-chain DNA fragments extracted from wild salmonid fish, N is derived from biological sources and designed to support tissue healing and offers unique reparative and anti-inflammatory properties.

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Nonsteroidal anti inflammatory drugs are often tried before injections are considered, especially for patients who may not respond to or tolerate these medications.

Benefits of Knee Injection Treatment

healthy knee
knee pain
after knee Polynucleotide (PN) conjuran injection

Knee injections are a commonly used method to help manage knee pain and osteoarthritis, Offering a non-surgical option to help improve mobility and reduce discomfort. By delivering targeted therapies such as hyaluronic acid directly into the knee joint, these injections help reduce pain and inflammation, making daily activities easier and more enjoyable. Many patients report pain relief, though results can vary, which can lead to a better quality of life and greater independence.

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One of the key advantages of knee injections is their ability to delay or even prevent the need for surgery, especially for individuals with mild to moderate osteoarthritis. This treatment option is particularly valuable for those who want to maintain an active lifestyle without the risks and downtime associated with surgical procedures. Knee injections are widely use for managing knee pain, and they are often recommended as part of a comprehensive treatment plan tailored to each patient’s needs.

Polynucleotide (PN) knee Injections

PN injections are a suitable choice for their regenerative and anti-inflammatory effects—especially for patients with early-stage osteoarthritis or cartilage wear.

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Key benefits of PN therapy include:

  • Enhanced cartilage healing (improved tropism)

  • Strong anti-inflammatory effects

  • Reduced joint friction and pain

  • Improved knee mobility

  • Low adverse reaction rates

  • No steroid ingredients

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Unlike hyaluronic acid (which mainly lubricates), PN also creates a cellular environment that encourages collagen synthesis and tissue repair, helping to address root causes of degeneration.

Gel Injection Benefits

Gel injection, or viscosupplementation, is a specialized knee injection treatment that involves introducing hyaluronic acid into the knee joint. This natural gel acts as a lubricant and shock absorber within the joint, helping to reduce friction and ease movement. For patients with osteoarthritis or cartilage wear, gel injections can provide much-needed pain relief and support healthier joint function.

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The benefits of gel injection go beyond simple lubrication. Hyaluronic acid also helps to reduce inflammation in the knee, creating a more favorable environment for cartilage health and potentially slowing the progression of joint degeneration. Because it is a minimally invasive procedure, gel injection is often combined with other treatment options, such as physical therapy and pain medications, to maximize results. Patients typically notice improved comfort and mobility, making gel injection A non-surgical option often used for symptom relief from knee pain.

Risks and Side Effects

While generally safe, knee injections may cause some temporary side effects that patients should be aware of:

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  • Injection site soreness

  • Temporary stiffness

  • Rare allergic reactions or infections

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Consult your doctor to discuss any concerns and understand potential side effects.

Preparation for Knee Injections

Preparing for your knee injection helps ensure a smooth procedure and better outcomes:

  • Disclose medical history and medications

  • Imaging (X-ray/MRI) may be required

  • Follow pre-procedure instructions from your provider

What to Expect During the Procedure

Knee injections are quick and typically well-tolerated with minimal discomfort:

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  • Takes 30 minutes to an hour

  • May involve the injection of hyaluronic acid to the affected area

  • Mild discomfort may occur

  • Patients may be asked to bend their knee afterward to help distribute the medication to the entire joint

After Care and Recovery

Proper aftercare is key to minimizing risks and supporting recovery after your injection:

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  • Resume light activities after the injection

  • Avoid strenuous exercise for few days

  • Monitor for signs of infection

  • Follow any prescribed rehabilitation (e.g., physical therapy)

Recovery and Rehabilitation

Recovery after knee injection treatment is generally straightforward, allowing most patients to return to their normal routines within a short period. The procedure is usually performed on an outpatient basis, so you can go home the same day. However, to achieve the best possible pain relief and joint function, it is important to follow a structured rehabilitation plan after the procedure.

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This plan may include physical therapy, gentle exercises, and lifestyle adjustments designed to strengthen the muscles around the knee and support long-term joint health. Patients are typically advised to avoid high-impact activities, such as running or jumping, for several weeks after the injection to allow the joint to heal properly. By adhering to your rehabilitation program, you can maximize the benefits of your treatment and enjoy lasting improvements in knee comfort and mobility. In Singapore, many clinics offer comprehensive aftercare and rehabilitation services to support your recovery journey.

Treatment Plan: PN Injections Protocol

PN injections follow a structured schedule for optimal regenerative and anti-inflammatory benefits:

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  • 3 sessions: Day 1, Day 8, Day 15

  • Maintenance: Every 9–12 months, depending on lifestyle and severity

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This protocol ensures optimal regenerative and anti-inflammatory effects over time. Most patients can resume normal activities shortly after each session.

Who is a Good Candidate

Certain individuals are better suited for knee injections based on their condition and medical history:

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  • Individuals with mild to moderate osteoarthritis

  • Those not responding to pain medications or physiotherapy

  • Patients seeking non-surgical options

  • People without bleeding disorders, infections, or certain allergies

Knee Pain Management and Prevention

Long-term relief from knee pain also requires lifestyle changes and joint care strategies:

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  • Combine injections with physical therapy and lifestyle changes

  • Maintain a healthy weight

  • Avoid high-impact activities

  • Use proper posture and lifting techniques

A Regenerative for Knee Pain

Preventing and managing knee pain is not just about treatment—it’s about empowering your joints through proactive care.

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Regular exercise, weight management, and lifestyle modifications can help slow joint degeneration and support better outcomes from therapies like PN injections.

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If you’re looking for a non-surgical, and solution to reduce knee pain in Singapore, PN injections may be the right option for you.

FAQ

Is it painful to have a knee injection?

Mild discomfort is common, but most patients tolerate it well.

Can I walk after a knee injection?

Yes, light walking is usually allowed right after the injection.

How much do knee injections cost?

Prices vary, but they typically range from $100 to $1,000 depending on the type.

Do knee injections really work?

Yes, many patients experience pain relief and improved mobility, but results vary and depend on each individual case

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