Linerase vs. Rejuran Healer (PDRN): A Comprehensive Comparison
- fundamentalmedical
- 3 days ago
- 3 min read
Injectable treatments targeting skin aging have advanced significantly in recent years. Two widely used options for skin regeneration are Linerase and Rejuran Healer, both of which aim to stimulate the skin’s natural repair processes. While both are injectable therapies, they differ in composition, mechanism of action, and clinical application. The increasing popularity of regenerative aesthetics is linked to a growing preference for natural and minimally invasive procedures.
What is Linerase?
Linerase is an injectable formulation composed of micronized Type I collagen derived from equine sources. It is designed to stimulate fibroblast activity, promoting new collagen synthesis and supporting the skin’s structural integrity. The newly activated fibroblasts produced by Linerase use injected amino acids to create new Type III collagen. Linerase is primarily used for areas of the skin with decreased collagen levels, such as the face, neck, and hands. It is considered a biocompatible treatment, though rare allergic reactions to animal-derived collagen are possible.
Key points about Linerase:
Active ingredient: Micronized Type I collagen (equine-derived)
Mechanism: Stimulates fibroblasts to produce endogenous collagen
Clinical use: Improves skin elasticity and firmness, supports dermal structure
Injection depth: Mid-to-deep dermal layers
What is Rejuran Healer (PDRN)?
Rejuran Healer uses polynucleotides (PDRN), which are fragments of DNA derived from salmon. These DNA fragments have wound-healing and anti-inflammatory properties, and they stimulate fibroblasts to produce collagen and extracellular matrix components. Rejuran Healer is typically used for superficial skin rejuvenation, addressing fine lines, skin texture irregularities, and early signs of aging. Additionally, Rejuran contains hyaluronic acid, which helps in providing deep hydration to the skin.
Key points about Rejuran Healer:
Active ingredient: Polynucleotides (salmon DNA fragments)
Mechanism: Anti-inflammatory, promotes tissue repair and collagen production
Clinical use: Improves skin texture, reduces fine lines, supports skin hydration
Injection depth: Superficial to mid-dermal layers
Comparative Overview
Feature | Linerase | Rejuran Healer (PDRN) |
Active Ingredient | Micronized Type I Collagen (equine-derived) | Polynucleotides (Salmon DNA fragments) |
Mechanism | Stimulates fibroblast activity for collagen synthesis | Reduces inflammation and promotes tissue repair |
Primary Benefits | Improves skin elasticity and dermal support | Improves skin texture, reduces fine lines, enhances hydration |
Treatment Areas | Face, neck, hands, areas with collagen loss | Face, especially under-eye area, fine lines, early aging signs |
Ideal Candidates | Individuals with structural collagen depletion | Individuals with early signs of aging or minor skin texture issues |
Injection Depth | Mid-to-deep dermis | Superficial to mid-dermis |
Side Effects | Mild redness, swelling, rare allergic reaction | Mild redness, bruising, swelling |
Treatment Frequency | 2–3 sessions, spaced weeks apart | 3–4 sessions, spaced weeks apart |
Clinical Considerations
Mechanism of Action:
Linerase mainly provides a structural support by adding collagen that stimulates skin repair.
Rejuran Healer primarily acts as a regenerative stimulus, promoting healing at a cellular level.
Targeted Use:
Linerase is more suitable for skin with moderate to severe collagen loss.
Rejuran Healer is suitable for early aging signs or minor skin texture concerns.
Safety Profile:
Both treatments are generally well-tolerated.
Allergic reactions are rare but slightly more relevant with animal-derived collagen (Linerase).
Treatment Protocols:
The number of sessions varies depending on the severity of skin aging, patient response, and practitioner recommendation.
Conclusion
Linerase and Rejuran Healer are both injectable therapies that aim to improve skin quality by stimulating natural regenerative processes. Linerase focuses on collagen restoration and structural support, whereas Rejuran Healer (PDRN) targets skin regeneration, repair, and texture improvement. Rejuran focuses on improving overall skin quality, leading to a healthy, glass skin effect. Choosing between the two depends on the patient’s skin condition, aging stage, and clinical goals. Professional consultation with a licensed practitioner is essential for determining the most suitable approach.
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