Profhilo vs Profhilo Structura: Which HA Skin Booster Is Right for You in Singapore?

fundamentalmedical
2 days ago
7 min read

Introduction

In recent years, skin booster injections have become one of the most sought-after aesthetic treatments in Singapore — and among them, Profhilo has gained a stellar reputation for improving hydration, elasticity, and overall skin radiance.

Now, a newer formulation known as Profhilo Structura (sometimes called the next-generation Profhilo) is making waves. While both are hyaluronic-acid (HA) based bio-remodelling injectables, they differ in formulation, purpose, and lifting power. Unlike traditional skin boosters that primarily focus on hydrating the dermis and improving superficial skin appearance, Profhilo Structura offers deeper structural support and facial contouring by targeting the superficial fat layer.

If you’ve been wondering whether to go for Profhilo or Profhilo Structura, this guide breaks down how each works, their benefits, and which may be better suited for your skin goals — all tailored to the Singapore context. Some patients choose Profhilo Structura over other options because it is ideal for those seeking subtle facial support, restoration of firmness, and gentle contouring, especially as a gentler alternative for early signs of aging.

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What Is Profhilo?

Profhilo is an injectable hyaluronic acid (HA) treatment designed to rejuvenate and hydrate the skin from within. This is the original Profhilo treatment, which has become a popular choice for those seeking non-surgical skin rejuvenation. Unlike fillers, which add volume or contour, Profhilo spreads evenly beneath the skin to stimulate collagen and elastin production.

It contains a patented hybrid of high-molecular-weight HA (for structure) and low-molecular-weight HA (for deep hydration). This unique dual combination allows the Profhilo treatment to act as a bio-remodeller rather than a filler — as a minimally invasive procedure, it improves firmness, elasticity, and overall skin texture.

Profhilo is ideal for treating areas that often show early ageing signs, such as:

Cheeks and lower face
Neck and jawline
Décolletage and hands

1.1 📖 Scientific Note: Hyaluronic Acid

A clinical study published in The Journal of Cosmetic Dermatology found that intradermal injections of hybrid HA formulations significantly improved skin elasticity, hydration, and texture after two sessions spaced one month apart (Zachary et al., 2020).

What Is Profhilo Structura for Facial Structure?

Profhilo Structura is the newer generation of the same HA bio-remodelling family. It builds upon the original formula but is designed for deeper structural support — targeting skin laxity, contour definition, and mild tissue sagging. The Profhilo Structura treatment is a minimally invasive procedure specifically developed to improve facial firmness, skin texture, and natural contour by targeting key structural components beneath the skin.

While Profhilo focuses on skin quality, Structura focuses on skin architecture. Profhilo Structura targets the superficial fat pads and deeper layers of the skin, including subcutaneous adipose tissue and fat cells, to restore facial support and promote natural rejuvenation. It has a more cohesive and viscous formulation, meaning it stays longer in the injected area, offering subtle lifting and contour enhancement while still delivering hydration.

Structura is typically injected slightly deeper than the classic Profhilo, allowing it to support the mid-face and jawline more effectively. The treatment is especially effective for the mid and lower face, where age-related changes in facial fat compartments and fat pads contribute to sagging and volume loss.

Clinics in Singapore have described Structura as the “bridge between skin boosters and biostimulators” — it retains the glow of Profhilo but adds light volumising and tissue support. By stimulating adipose tissue and superficial fat pads, Profhilo Structura helps restore youthful contours and improve facial structure.

🔬 Key Differences: Profhilo vs Profhilo Structura

Aspect	Profhilo (Original)	Profhilo Structura (Enhanced)
Purpose	Deep hydration, skin elasticity, and glow	Structural support + hydration + mild lifting
HA Formulation	Hybrid low- & high-molecular-weight HA	More cohesive, higher-density HA matrix
Injection Depth	Superficial subdermal layer	Deeper subdermal / supraperiosteal layer
Spreadability	Wide diffusion for even skin hydration	More localized, maintains structure for lift
Target Area	Whole face, neck, chest, hands	Jawline, cheeks, temples, mid-face
Result Focus	Radiance, elasticity, hydration	Firmness, contouring, skin support
Duration	6–9 months	9–12 months (may vary by metabolism)
Downtime	Minimal – mild swelling or redness	Slightly more injection points, mild tenderness

Profhilo and Profhilo Structura are both innovative injectable treatments designed to improve skin quality and structure. Unlike traditional fillers and traditional skin boosters, Profhilo Structura works by stimulating the superficial fat layer rather than simply adding volume or hydrating the dermis. Profhilo is not a dermal filler, but a bio-remodelling treatment that offers natural improvements in skin quality and structure. Traditional fillers are gels that restore volume and shape, while Profhilo treatments focus on skin rejuvenation, hydration, and subtle structural support for a more natural look.

💡 Summary

Think of Profhilo as a hydrating skin booster, and Profhilo Structura as a skin-strengthening bio-booster.

Benefits of Each Treatment

Profhilo (HA Skin Booster):

Deeply hydrates from within the dermis
Improves elasticity and smoothness
Reduces fine lines and crepiness
Gives a natural, “glass-skin” glow
Minimal downtime, ideal for first-timers

Profhilo Structura (Enhanced HA Booster):

Provides hydration plus subtle lift
Adds firmness and contour to lower face or jawline
Strengthens skin architecture for mild sagging
Suitable for patients seeking stronger rejuvenation
Longer-lasting collagen stimulation

💡 Who Is It For?

Concern / Skin Type	Recommended Treatment
Dehydrated, dull, or thin skin	Profhilo
Mild sagging around jawline / cheeks	Structura
Younger patients (late 20s – early 30s) for prevention	Profhilo
Mature skin (mid-30s and above) needing support	Structura
Patients new to injectables or seeking their first treatment	Profhilo
Patients already used to skin boosters, seeking “next step”	Structura

Profhilo is suitable for those considering their first treatment with injectables, offering gentle skin hydration and improvement. Some patients choose Profhilo Structura for enhanced facial support and contour, especially when looking for a targeted, subtle lift as a gentler alternative to traditional fillers.

🤝 Combination Treatments with Dermal Fillers

For those seeking a truly transformative approach to facial rejuvenation, combination treatments with dermal fillers and Profhilo Structura are becoming increasingly popular in Singapore’s leading cosmetic skin clinics. By pairing these two advanced injectables, you can address a wider range of skin concerns and achieve more natural, long-lasting results.

How does this synergy work?

While Profhilo Structura is designed to provide deep structural support, stimulate collagen, and improve overall skin quality, dermal fillers are expertly used to restore lost facial volume and enhance specific facial features. When used together, they not only target sagging skin and skin laxity but also help to restore facial structure and youthful contours.

This combination is especially effective for those experiencing early signs of ageing, such as mild sagging, superficial fat loss, or a decline in skin elasticity. Dermal fillers can replenish volume in areas like the cheeks or temples, while Profhilo Structura works to strengthen the skin’s architecture and boost hydration from within. The result is a more youthful appearance, with firmer, tighter skin and improved skin tone and texture.

Most patients notice that their facial features appear subtly lifted and refreshed, with natural improvements in both skin firmness and facial support. By addressing both the underlying structure and the surface quality of the skin, combination treatments can help you achieve your skin goals more efficiently than with a single treatment alone.

If you’re considering combination treatments to improve skin quality and restore facial support, consult with an experienced practitioner at a reputable cosmetic skin clinic. They can tailor a plan that best suits your unique facial anatomy and desired outcome, ensuring you enjoy the full benefits of both Profhilo Structura and dermal fillers for a more youthful, radiant look.

🩺 Treatment Process in Singapore

Both treatments follow a similar clinical process:

Consultation – Your doctor assesses skin type, elasticity, and injection depth needed.
Preparation – Skin is cleansed; numbing cream applied.
Injection –
Profhilo: The doctor will identify the specific treatment area and administer tiny injections into the superficial dermis at strategic “Bio Aesthetic Points” for minimal discomfort.
Structura: The doctor will also determine the treatment area and use tiny injections deeper, sometimes along bone planes for structural support.
Recovery – Mild bumps or redness resolve within 24–48 hours. Patients are advised to protect the skin from sun exposure to maintain optimal results.
Maintenance – Typically, how many treatments are needed for best results? Most patients require 2 sessions, one month apart; results improve progressively over weeks.

Results & Longevity

Profhilo: Radiance and hydration appear within 1–2 weeks, with many patients noticing visible improvements in skin quality and firmness even after the first treatment. Full results peak at 4–6 weeks and last 6–9 months. Patients often ask, "how long does Profhilo last?"—the benefits, such as enhanced collagen remodelling and skin improvement, typically persist for several months, depending on individual skin condition and treatment frequency
Profhilo Structura: Gradual improvement in lift and firmness is seen in 3–4 weeks, with visible improvements continuing to develop, and results lasting 9–12 months due to its denser HA matrix.

Consistency is key — most Singapore clinics recommend a maintenance session twice a year for optimal results.

⚠️ Safety & Considerations

Both treatments are clinically safe and HSA-approved. Side effects are generally mild: redness, swelling, bruising, or temporary tenderness at injection sites.

Since Profhilo Structura is injected deeper, proper anatomical understanding by an experienced doctor is essential to avoid unevenness or nodules. Always ensure treatment is done by a MOH-licensed aesthetic clinic in Singapore.

Profhilo vs Profhilo Structura: Which Should You Choose?

If you’re in your late 20s to early 30s or just beginning to notice dullness and fine lines, Profhilo is an excellent entry-level HA skin booster. It restores hydration and elasticity naturally.

If you’re in your mid-30s and above, experiencing mild sagging or volume loss, Profhilo Structura might suit better — offering a subtle lifting effect while maintaining hydration.

Both treatments complement each other and can be used sequentially — many patients start with Profhilo for overall glow, then move to Structura for deeper firming. Patients may choose Profhilo Structura for its targeted support, gentle approach to early aging, and ability to restore facial firmness and contour based on their specific aesthetic goals.

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