Rejuran HB vs HB Plus: Understanding the Differences
- fundamentalmedical
- 2 days ago
- 3 min read

Introduction to Polynucleotide Skin Treatments
Rejuran HB Plus is an upgraded version of Rejuran Healer that adds hyaluronic acid (HA) for hydration and lidocaine for pain reduction. Polynucleotide-based skin treatments like these are injectable solutions designed to support skin repair, regeneration, and hydration. These treatments leverage naturally occurring compounds to improve skin elasticity, texture, and overall appearance. Over time, polynucleotides (PN) help stimulate skin regeneration, making them a non-surgical approach to maintaining healthy skin.
Rejuran HB and Rejuran HB Plus are two formulations commonly used for skin hydration and rejuvenation. While both share similar base ingredients, they differ in composition and additional features that affect comfort and treatment outcomes.
How Rejuran HB and HB Plus Work
Both Rejuran HB and HB Plus contain polynucleotides (PN) and hyaluronic acid (HA). PN supports natural skin repair and regeneration, while HA provides hydration to improve skin elasticity, tone, and texture.
The primary difference lies in pain management and formulation enhancements: Rejuran HB Plus includes lidocaine, which reduces injection discomfort, whereas Rejuran HB does not. Both formulations aim to stimulate collagen production indirectly through cellular repair mechanisms, promoting healthier skin over time.
Key Features of Rejuran HB and HB Plus
Feature | Rejuran HB (PN + HA) | Rejuran HB Plus (PN + HA + Lidocaine) |
Active Ingredients | Polynucleotides (PN), Hyaluronic Acid (HA) | Polynucleotides (PN), Hyaluronic Acid (HA), Lidocaine |
Primary Benefits | Deep hydration for dehydrated skin, skin regeneration, improved elasticity and texture | All benefits of HB with added comfort, enhanced hydration, and a visible “water glow” effect |
Pain Level | Injections can be uncomfortable for some | Lidocaine reduces pain by over 50% compared to standard HB |
Ideal For | Patients seeking deep hydration and regenerative effects | Patients who want hydration and regenerative benefits with reduced injection discomfort |
Choosing Between Rejuran HB and HB Plus
The decision between Rejuran HB vs HB Plus primarily depends on pain tolerance and individual skin goals.
Rejuran HB: Suitable for individuals focused on deep hydration and skin rejuvenation who are comfortable with standard injection discomfort.
Rejuran HB Plus: Recommended for those who desire the regenerative and hydrating effects of HB while minimizing pain during the procedure.
In cases where maximum skin repair is the priority and additional hydration or pain management is not required, the standard Rejuran Healer formula may be appropriate.
Summary of Differences
While both Rejuran HB and HB Plus provide hydration and stimulate skin regeneration, the Plus version offers enhanced comfort due to the inclusion of lidocaine and may give a more immediate hydrating effect from hyaluronic acid. Understanding the differences helps in selecting the most suitable option based on treatment goals and comfort preferences.
Conclusion
Rejuran HB and HB Plus represent variations of polynucleotide-based injectable treatments designed to support skin hydration and repair. HB focuses on deep hydration and regenerative benefits, while HB Plus enhances the experience with pain reduction and additional hydration. Selecting the appropriate formulation depends on individual priorities, pain tolerance, and desired skin outcomes. Consulting with a qualified professional can help determine the best treatment approach.
FAQ
What is the difference between rejuran HB and rejuran HB Plus?
The difference between Rejuran HB and Rejuran HB Plus is that HB Plus includes lidocaine for reduced injection pain in addition to hyaluronic acid for hydration, while standard HB provides hydration and regenerative benefits without pain reduction.
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